Until now, a few cases of occupational asthma induced by QACs have been described and their involvement in contact dermatitis has been documented. So far I haven’t been able to find any shampoos or conditioners without quats, but I’m apparently very allergic and need something… anything! Also, if you don’t mind me asking, how did you discover you had an allergy/sensitivity to quats? NAME 1.1 Substance Quaternary ammonium compounds 1.2 Group Benzalkonium Chloride Benzethonium Chloride Cetalkonium Chloride Cetrimide Cetrimonium Bromide Cetylpyridinium Chloride Glycidyl Trimethyl Ammonium Chloride Stearalkonium … Last updated: 16/12/2020. The toxic effects of five Quaternary Ammonium Compounds (QACs) that are widely used as active ingredients in personal care products were assessed using the bioluminescent bacterium Aliivibrio fischeri (formerly Vibrio fischeri) (Microtox® test system). Save my name, email, and website in this browser for the next time I comment. In other words, except benzalkonium chloride, I am okay with quaternary ammonium compounds when you use them knowingly. My son is prone to coughing fits as well and I haven’t been able to figure out what his trigger(s) is yet. The Skin Deep database also rates behentrimonium chloride 3-4 and puts it on the EWG’s unacceptable list of ingredients for the same reason. To be on the safe side, I recommend not using them on your baby, especially if she has little hair. Don't subscribe Yet, the study does not mention behentrimonium chloride, only benzalkolnium chloride and didecyldimonium chloride. Please enable it to take advantage of the complete set of features! After hours of research, I still do not see how the EWG decided that all quaternary ammonium chemicals are a subject of reproductive toxicity concern. The quaternary ammoniums are used to provide antistatic, antibacterial, emulating and other properties in a range of formulations like hair conditioners, cosmetics, in fabric softeners and in cleansing and disinfecting products. QUATERNARY AMMONIUM COMPOUNDS International Programme on Chemical Safety Poisons Information Monograph G022 (Group PIM) Chemical 1. EWG Skin Deep Database Rating/Safety Data Availability, American Contact Dermatitis Society, 2017 Allergen Series, 2020 CA Proposition 65, Chemicals known to cause cancer or reproductive toxicity, Guar hydroxypropyltrimonium chloride (65497-29-2). Anyway, I did end up finding a shampoo/conditioner that works for me! Although it may cause eye irritation at concentrations of 2% and above, all the eye products use 0.3% or less of trimonium ingredients, well below these concentrations. Therefore, the Panel advised formulators to consider this factor in their product formulations. CAS number: 63449-41-2. One of the main allergens discovered by that was formaldehyde and formaldehyde releasers, which includes quats. Very toxic to aquatic life; may cause harm when swallowed; serious eye damage. NIH In other words, if your hair is dry, frizzy, and thin and you can barely comb it, most likely your shampoo and conditioner have no quats. 27479-28-3); n-hexadecyl dimethyl benzyl ammonium chloride … On the other hand, the 2006 CIR report deemed it safe in concentrations up to 0.1% as a free active ingredient. The experimental results showed a … My son has developed a pretty crazy sensitivity to them, and I have been having a hard time finding a shampoo that works for him.  |  Hello Select your address All Hello, Sign in. In addition, in its 2017 Allergen Series the American Contact Dermatitis Society lists none of them, except benzalkonium chloride, as core allergens. There is a group of chemicals that are very common in shampoos and conditioners but are rather controversial on the Internet. Your email address will not be published. Quaternary Ammonium Compounds SDS Safety Data Sheet for Quaternary Ammonium Compounds 117920. And I found no reproductive toxicity concern for behentrimonium chloride in other sources.  |  Their wide distribution in the work environment and also in private households brings about new occupational hazards. One of the advantages of quaternary ammonium disinfectants is that they don't damage clothing and carpets the way that bleach does. According to the European Scientific Committee on Consumer Safety (SCCS) report, rinse-off hair products can safely use it in concentrations up to 5.0% and leave-on hair and facial products up to 3.0%. Disinfectant quaternary ammonium compounds (Quats) have diverse uses in a variety of consumer and commercial products, particularly cleaning products. Quaternary ammonium compounds (QACs) are cationic surfactants. So, in this post, we will demystify the world of chemicals called quaternary ammonium compounds, or quats for short. First, stearalkonium chloride can also serve as a preservative and has a rating of 5 in the Skin Deep database. Just as the other quats we talked about above, the EWG includes it in the unacceptable list of ingredients because they believe that it may trigger asthma and may be toxic to human reproductive health. Thus, due to the lack of dermal penetration, there appears to be no genotoxic risk from the use of trimoniums in cosmetics. - Duration: 18:36. No wonder my skin was coming off in sheets. In addition, many other products have even worse ingredients: formaldehyde releasing preservatives, parabens, methylisothiazolinone or fragrance. It is a quaternary ammonium derivative of guar (aka cluster beans) that undergoes conversion with 3-chloro-2 hydroxypropyl trimethyl ammonium chloride. View Material Safety Data Sheet View Technical Data Sheet: Silquat A0-B [TOP] Shortest chain silicone distearyl quat. To start with, it belongs to a group of galactomannans, which are legume polysaccharides. Success! 2014 Mar;44(3):393-406. doi: 10.1111/cea.12215. QACs could play a role of sensitizers and irritants to the skin and mucous membranes. Information gathering. 1 Product Result | Match Criteria: Product Name, Property, Description 1.17920 ; colorimetric, 10-500 mg/L (quaternary ammonium), MQuant ® Supelco pricing. Thus, in animal studies, stearalkonium chloride did not show any harm to offspring even after exposure to big doses. They think, it may trigger asthma and be toxic to the human reproductive system and cite the study in the reproductive toxicology journal. It is suspected that particular QACs can display an immunologic cross-reactivity between each other and with other chemical compounds containing ammonium ion, such as muscle relaxants widely used in anesthesia. 2009 May;60(5):296-8. doi: 10.1111/j.1600-0536.2009.01534.x. Nevertheless, sometimes, you can find them even in baby washes. Do you have a list of any that you have found that don’t contain them? Gonzalez M, Jégu J, Kopferschmitt MC, Donnay C, Hedelin G, Matzinger F, Velten M, Guilloux L, Cantineau A, de Blay F. Clin Exp Allergy. Also, I recommend avoiding grapefruit seed extract, because it may contain benzalkonium chloride as a hidden ingredient. To begin with, these ingredients perform several functions. Characteristics of Selected Active Substances used in Disinfectants and their Virucidal Activity Against ASFV. P. 1 Quaternary Ammonium Compounds in Cleaning Products This information sheet reviews the recognition, assessment, and treatment of possible adverse health effects of prod- ucts containing alkyl dimethyl benzyl ammonium chlorides and several other quaternary ammonium compounds (QACs or “quats”) used in cleaning and disinfection. This paper reviews reports about the health effects of QACs. Required fields are marked *. Quaternary ammonium compounds, benzyl-C8-18-alkyldimethyl, chlorides . EC number: 264-151-6. The list of quats they gave me was pretty short and after some research on my end, realized that one of natural products new favorite substances to use, behentrimonium methosulfate, was a quat too. Quaternary ammonium compounds are a large class of chemicals used for their antimicrobial and antistatic properties. I'm Irina Webb, the trusted non-toxic consumer product researcher. Besides, it is not sensitizing at 0.25%, and not mutagenic. You can also subscribe without commenting. And in the leave-on facial cream products, it is safe up to 0.5%. It coincided with the introduction of a disinfectant containing both alkyl dimethyl benzyl ammonium chloride (aka benzalkolnium chloride) and didecyl dimethyl ammonium chloride (aka didecyldimonium chloride). I discovered that putting half of a vanilla bean pod (cut open) into it makes it smell awesome. At 0.1% reactions with caution, mild irritant, and/or low clinical relevancy. 1 General description. Occupational immediate-type contact allergy to didecyl methyl polyoxyethyl ammonium propionate. They are thought to be the chemical group responsible for anaphylactic reactions that occur with use of neuromuscular blocking drugs during general anaesthesia in surgery. But there were mixed results (nonirritant-slight-moderate) in concentrations above 1%. Consequently, combing is easier, and frizz is under control. They are also non-corrosive to metal pipes and other surfaces, another advantage over bleach. As with the above quaternary ammonium chemicals, the EWG cites the study in which I do not see stearalkonium chloride. Hence, the CIR Expert Panel concludes that behentrimonium methosulfate is safe in the present practices of use and concentration when formulated to be nonirritating. Then, we will talk about each of them individually from the standpoint of scientific research on their safety. Further, human dermal irritation studies yielded no irritation at 5.0% and no sensitization at 2.4%. Material Safety Data Sheet or SDS for Quaternary Ammonium Compounds 117920 from Merck for download or viewing in the browser. The food additive, quaternary ammonium chloride combination, may be safely used in food in accordance with the following conditions: (a) The additive contains the following compounds: n-dodecyl dimethyl benzyl ammonium chloride (CAS Reg. Hi, Shaneen: you can find some shampoos and conditioners in my Shampoo and Conditioner Rating Lists that don’t contain them. ", "I find your knowledge so helpful, to the point and like a gold mine. Test preparation Instrument-specific information Table 1 shows all of the instruments that have the program for this test. It will help you choose the right shampoo and conditioner for your hair type without even trying them. View Material Safety Data Sheet View Technical Data Sheet : Silquat CR 4000: A very-high molecular weight water-soluble quaternary ammonium polysiloxane. Clipboard, Search History, and several other advanced features are temporarily unavailable. When I first contacted the company, they claimed that their wipes contained water and pure grapefruit seed extract only. I find your knowledge so helpful, to the point and like a gold mine. https://ireadlabelsforyou.com/shampoo-rating-list/ ~Irina. It works by laying down millions of sword-shaped molecules, forming a positively-charged barrier on a surface. Conclusion about the quaternary ammonium compounds safety. True Botanicals and Wellnesse haircare products have them, too. The last member of the quaternary ammonium compounds family in this post is benzalkonium chloride. The Institute of Food Safety and Toxicology Danish Veterinary and Food Administration. In sum, the Panel considers guar hydroxypropyltrimonium chloride safe in present usage and concentrations (up to 2%). They also perform a coating function solving the problem of dry hair without flattening it. They are effective against most vegetative bacteria and enveloped viruses, and some fungi. Over 50 of our products can be sanitized with quaternary ammonium. Quaternary ammonium compounds are considered low-level disinfectants, as defined by the US Centers for Disease Control and Prevention. Quaternary ammonium compounds like n-alkyl C12-C14 dimethyl ethylbenzyl ammonium chloride have subsequently shown antimicrobial activity against both gram positive and negative bacteria 1 as well as a certain extent of antifungal activity 2 and certain actions against particular virus types 3. This site needs JavaScript to work properly. Also, the SCCS does not state any reproductive toxicity effects. If you use WaterWipes baby wipes, you might want to read my post about them. Moreover, there was no evidence of birth defects at 2.0% concentration. So, while it is plant-derived, there is a synthetic portion to it. On the other hand, they are not on the 2020 CA Proposition 65 list of chemicals known to cause cancer or reproductive toxicity. Additionally, it is safe in leave-on facial creams at up to 0.5%. Expand all Collapse all. Juszkiewicz M, Walczak M, Woźniakowski G. J Vet Res. However, all the eye products containing trimonium ingredients use 0.3% or less, well below these concentrations. NDC; 1: 78183-012-01 Home; News DailyMed Announcements; Get RSS News & … The Government of Canada recognizes that maintaining an up-to-date inventory of substances in … Very toxic to aquatic life; serious eye and skin irritant. Through polar attraction, this undetectable layer pulls in the negatively charged microbes, puncturing and electrocuting them. They may promote the development of airway allergy, however, the background mechanisms are still unclear and need to be further investigated. 453/2010 Date of issue: 10/11/2019 Version: 1.0 10/11/2019 EN (English) SDS Ref: 6335AU 1/9 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Thus, there is no data on its reproductive toxicity, carcinogenicity, dermal irritation or sensitization. The EWG also rates it 5, but lists it among the EWG’s restricted ingredients. Just like behentrimonium chloride, the EU restricts it to 1% as a preservative. Very toxic to aquatic life; toxic in contact with skin; causes severe skin burns and eye damage; harmful if swallowed. Notify me of followup comments via e-mail. 2015 Jun;33:296-304. doi: 10.1016/j.copbio.2015.03.018. Alternatively, the European Chemicals Agency (ECHA) emphasizes their toxicity to aquatic life and harmful effects on the organs. However, the ECHA does not specify the concentrations of these ingredients that may cause the harm described. We use a silane quaternary ammonium compound, also called a silane quat. Epub 2015 Apr 10. Quaternary Ammonium Compounds SDS Safety Data Sheet for Quaternary Ammonium Compounds 117920. The Skin Deep database used to rate it 1, but now it rates behentrimonium methosulfate 3-4. Medline Plus ... VIR-U-CLEAN DISINFECTANT CLEANING WIPES- 0.2% quaternary ammonium salt cloth If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be specified as such. Later, it turned out to be a different story. For me, I have eczema and I went to a dermatologist to get patch testing. I have used only plain soap on my son since his birth, and his hair looks shiny, hydrated, and healthy. It also adds it to the EWG’s unacceptable list as toxic to the human reproductive system and an asthma trigger. Finally, in 1982 the Cosmetic Ingredient Review Expert Panel concluded that stearalkonium chloride was not a sensitizer or an irritant in concentration currently used in personal care products. Hi Heidi, I’m so sorry to hear about your son! Introduction of a cleaner containing ADBAC+DDAC in the vivarium caused neural … Epub 2014 Oct 31. Skip to main content.us. Since efflux pumps are believe to account for at least some of the increased tolerance … Thus, the Panel noted that it can increase the dermal penetration of other chemicals (e.g., betamethasone phosphate). In fact, they add volume to your hair. "Quaternary ammonium compounds can cause toxic effects by all routes of exposure including inhalation, ingestion,dermal application and irrigation of body cavities. This post may contain affiliate links, which means that if you click on the affiliate link and buy an item, I’ll receive commissions. Further, the CIR states that the available data on many of the trimoniums are sufficient to support the safety of the entire group. According to the 2012 CIR Safety Assessment of Trimoniums in Cosmetics, this kind of quaternary ammonium compounds is currently used at 0.0005% to 10% in rinse-off and at 0.001% to 4% in leave-on products. The conditions necessary to attain disinfection with quats depend on concentration and contact time. Curr Opin Biotechnol. Bis-quaternary Ammonium Salt Market 2020 Determined By Manufacturing Summary, Business Profile And Estimate To 2027 ... 2020 The Year On A Positive Note | Beal Pro, Bei Bei Safety, Capital SALA, CATU, Cresto Safety Ab, DMM Professional, elcom SAS, Fallsafe-Online Lda, Gunnebo Industrier AB, IRUDEK 2000 S.L., item industrial applications, JSP, Kaya Grubu, Mine Safety Appliances … I highly recommend avoiding benzalkonium chloride. Nevertheless, it puts it on the EWG’s restricted list of ingredients, which means that they may be acceptable after their verification process. This paper reviews reports about the health effects of QACs. Quaternary ammonium compounds are cationic detergents, as well as disinfectants, and as such can be used to remove organic material. ® SQ Quaternary Ammonium Disinfectant Safety Data Sheet according to Regulation (EC) No. These quarternary ammonium compounds (QACs) were identified for action under the Chemicals Management Plan (CMP). Moreover, it puts it on the EWG’s unacceptable list of ingredients because they believe it may trigger asthma and be toxic to human reproductive system. Some quaternary ammoniums are poorly degraded and some are highly toxic to aquatic organisms. It’s made by Nature Sustained and is made with fermented soapberries. As it follows from its name, cetrimonium chloride is a trimonium type of quaternary ammonium compounds. Jon Jandai Life is Easy Recommended for you SAFETY DATA SHEET QUATERNARY DISINFECTANT CLEANER 903810-03 2 / 12 IN EYES: Rinse cautiously with water for several minutes. Admittedly, there was a data gap regarding carcinogenic, mutagenic, or teratogenic effects of stearalkonium chloride. You have saved me so much time and have taught me so much.” Toni.  |  Quaternary ammonium compounds, benzyl-C12-16-alkyldimethyl, chlorides Regulatory process names 3 Translated names 23 CAS names 1 IUPAC names 13 Other identifiers 9 Print infocard Open Brief Profile Open Substance Regulatory Obligations The EU restricted its use as a preservative to 1%. On the other hand, I believe quaternary ammonium ingredients are not as bad as the EWG views them. So, let us look at other scientific sources to find this information about each of these ingredients.